Weight Management · 10mg / 20mg vials
Semaglutide(GLP-1)
Semaglutide mimics the GLP-1 hormone, binding to receptors in the pancreas, gut, and brain. It reduces hunger signals, slows stomach emptying, increases insulin release in response to meals, and suppresses glucagon. It is the most widely studied research peptide in the weight management category.
Concentration reference
Standard mix: 10mg vial + 1mL BAC water = 10mg/mL. Each 0.025mL (2.5 IU) = 250mcg.
Dosing schedule
| Phase / Use | Dose | Draw Volume | Frequency | Notes |
|---|---|---|---|---|
| Weeks 1–4 | 250mcg | 0.025mL (2.5 IU) | Once weekly | Lowest starting dose — critical for GI tolerance |
| Weeks 5–8 | 500mcg | 0.05mL (5 IU) | Once weekly | First escalation |
| Weeks 9–12 | 1mg | 0.1mL (10 IU) | Once weekly | Most common maintenance dose |
| Weeks 13–16 | 1.7mg | 0.17mL (17 IU) | Once weekly | Higher range |
| Weeks 17+ | 2.4mg | 0.24mL (24 IU) | Once weekly | Maximum research dose — full satiety effect |
Reconstitution calculator
Concentration
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Draw volume
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On insulin syringe
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U-100 insulin syringe: 1 mL = 100 IU. Calculation for research reference only.
Injection sites
Abdomen (fastest), outer thigh (slower), upper arm. Always rotate. Note: Abdomen gives approximately 20% faster absorption vs. thigh.
Timing
Same day each week. At least 2 hours after a meal is optimal, though clinical protocols allow any timing.
Cycle length
16–20 weeks. 4–6 week break. Can extend maintenance at 1mg–2.4mg for longer protocols.
Stacking
Commonly stacked with NAD+ for cellular support. Some protocols add BPC-157 for gut health during adaptation phase.
Warnings
- ⚠The 250mcg start is important — jumping to 1mg on week 1 produces significant nausea in most research subjects
- ⚠GI side effects are highest during the first 4 weeks of any dose escalation
Tips
- ✔If moving from 1mg to higher doses, try a 2-week intermediate at 1.4mg before jumping to 1.7mg
- ✔Once at 2.4mg, many subjects reduce back to 1mg maintenance — an effective long-term strategy