Weight Management · 10mg / 20mg vials
Retatrutide
Retatrutide is a triple agonist targeting GLP-1, GIP, and glucagon receptors — the most comprehensive metabolic peptide currently in research. The glucagon receptor action adds fat oxidation and thermogenesis on top of the appetite suppression and insulin signaling of dual agonists.
Concentration reference
Standard mix: 10mg vial + 1mL BAC water = 10mg/mL. Each 0.1mL = 1mg (1,000mcg).
Dosing schedule
| Phase / Use | Dose | Draw Volume | Frequency | Notes |
|---|---|---|---|---|
| Weeks 1–4 | 2mg | 0.2mL (20 IU) | Once weekly | Foundational tolerance period — do not skip |
| Weeks 5–8 | 4mg | 0.4mL (40 IU) | Once weekly | First escalation |
| Weeks 9–12 | 8mg | 0.8mL (80 IU) | Once weekly | Second escalation — significant appetite reduction expected |
| Weeks 13–16 | 12mg | 1.2mL — split across two draws | Once weekly | Research target dose for most protocols |
| Weeks 17+ | 12–16mg | Adjust proportionally | Once weekly | Max studied dose range — advanced only |
Reconstitution calculator
Concentration
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Draw volume
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On insulin syringe
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U-100 insulin syringe: 1 mL = 100 IU. Calculation for research reference only.
Injection sites
Abdomen, outer thigh, upper arm. Rotate every injection.
Timing
Once weekly, consistent day. With or without food. Morning preferred.
Cycle length
16–24 weeks. 6–8 week recovery. The extended escalation schedule means this is a longer-term protocol than semaglutide.
Stacking
NAD+ for cellular energy support. CJC-1295 stack not typically combined — focus on metabolic outcomes.
Warnings
- ⚠The 4-step escalation is mandatory — triple agonist activity amplifies GI effects if rushed
- ⚠If any escalation step causes significant discomfort, hold for 4 extra weeks before proceeding
Tips
- ✔Triple agonist action means effects compound with each escalation more than other GLP peptides
- ✔Glucagon receptor activity can increase thirst — maintain higher fluid intake throughout protocol
Common stacks
Maximum weight loss
Triple agonist + cellular energy — most comprehensive metabolic protocol.